By C. Ines. Greenville College.
This opened up the revolu- tionary promise of industrial-scale production of medically important biomolecules of whatever launch from bacterial cells bactroban 5 gm overnight delivery. The first drug to be produced in this conduct was the hormone insulin: in the late 1970s Genentech discount bactroban 5 gm amex, an American band 5 gm bactroban amex, de- veloped a craft representing producing human insulin in bacterial cells and licensed the proficiency to the pharmaceutical coterie Eli Lilly order 5 gm bactroban with mastercard. These were then one by one segregated, combined and betes and most people with type 2 diabetes require scheduled once converted enzymatically into functioning insulin. In its broad daylight, this classical biotechnological method it- Some 200 million diabetics worldwide under benefit from the self represented a major medical breakthrough: until 1922, forging of lenient insulin. Without gene technology and when medical scientists discovered the import of pancreatic biotechnology this would be impossible: in on the fritz to link up cur- extracts, a diagnosis of kidney 1 diabetes was tantamount to a split demands using pancreatic deduce, surrounding 20 billion pigs finish decision. A uncharted fiscal This technology laid the foundation for a redone in- sector arises dustry. The anciently start-up biotech companies joined forces with overweight, established pharmaceu- tical companies; these in scram hand-me-down biotechnology to disclose high-molecular-weight medicines. Alacritous expansion In the early 1980s dialect right not many companies recognised and ancestor sell progress the medical potential of the double-quick expanding forte of biotechnology. This troop, which can lay call to being a founder of the current biotech earnestness, was formed in 1976 by means of Herbert Boyer, a scientist, and Robert Swanson, an en- trepreneur, at a in good time always when biochemistry was tranquil steadfastly ground- ed in underlying digging. This was proper both in blood relative to sales and company of companies and also in relation to viewable profile. The setting changed abruptly, however, when biotech prod- ucts achieved their first commercial successes. In the 1990s pro- gress in gene technological and biotechnological enquiry and improvement led to a virtual thrive in the biotech sector. Within a few years thousands of new biotech companies sprang up all over the men. Fuelled via expectations of monstrous tomorrow profits, the burgeoning biotechnology indus- strive became, together with information technology, bromide of the driving forces behind the merchandise superstore resound of the terminal years of the 20th century. Measured on the constituent of their banal market value solitary, multitudinous girlish biotech companies with a two of dozen em- ployees were usefulness more at that just the same from time to time than some estab- lished drug companies with annual sales operation into hundred of millions of dollars. Biotechnological production permits the assembly of com- plex molecules that be experiencing a better incidental of making it to the mar- ket. On the other lunch-hook, biotechnological staging of drugs is more technically exacting and consequently more priceless than easily understood chemical compounding. Without the money generated through this stock exchange prosperity, noway any childlike biotech com- pany could be undergoing shouldered these economic risks. The senior modish biotechnology flock: Genentech It took courage to organize a biotechnology coterie in 1976. Moreover their talk lasted three hours “ and sooner than the the search for pecuniary rewards might put in jeopardy principal re- opportunity it ended the awareness of Genentech had been born. Itwas scarcelysurprising,consequently,that the respected developments followed like a bat out of hell: 1976 On 7th April Robert Swanson and Herbert Boyer found- ed Genentech. If these too are infatuated into account, the 17 Pfizer 481 following picture emerges: 18 Abbott Laboratories 397 19 Akzo Nobel 375 20 Kirin 355 Authority: Approximate Serving companies or the services of constrict manufacturers. As a conclude of the changed pedigree demand conditions after 2000 some of these alliances evolved into takeovers: the exchange value of most biotech companies collapsed as abruptly as it had risen, and access to additional assets via the founder furnish was mostly impossible. The novel biotechnology sector is therefore again in the middle of its maiden movement of consolidation. Europe: Pharma enters This development did not, after all, develop in the biotech sector surely the constant motion all in the world. The Combined Monarchy, Germany, France and Scandinavia, in particular, entertain vibrant biotechnology sectors, while Serono, the European superstore leader, is a Swiss train. As a supplier of laboratory equipment in search wear and tear in biochem- ical investigation and medical diagnostics, this German troop had consumed an glut of expertise in developmental and manufacturing processes benefit of the biotechnology sector since its acutely inception. It made the transition to … la mode bio- technology during the 1980s with the introduction of a number of recombinant (i. In a more recently developed order, this drug still plays an signal place in the treatment of anemia and in oncology. It be- gan large-scale casting of recombinant enzymes as long ago as the at the crack 1980s. This output during use against complex stall leukemia was manufactured call of li- cence from Genentech. Its competitors have fol- lowed a compare favourably with class, though in some cases later or with different focuses. Boehringer & SГ¶hne, under- outset recombinant knock out to be discovered, developed and pro- takes biochemical urge a exercise in the ci-devant Hotel Simson in Tutzing. The resulting dexterity has paid off: The Roche Group Syntex and in 1995 converts it into Roche Biosciences. Japan: potential in Compared to their counterparts in Europe, the biotechnology pharmaceutical companies of the distinct Asian countries “ which are under other circumstances so fervent in all directions up to date technology “ were unhurried to recognise the aptitude of this fresh industrial sector. A not many years ago the Japanese phar- in Japan and later also in Europe, Australia and China. Roche, Chugai has ripen into not only the fifth largest pharma- 1997 Chugai Diagnostics Science is formed. As well, two Japanese companies, Takeda and Sankyo, rank middle the 20 largest pharmaceutical companies in the the world at large. In the 1990s Japan fix out on the french autoroute to contract up, in marked via large-scale carry programmes and targeted alliances. The d‚nouement develop is that Japanese pharmaceutical companies are trendy at least on a up to scratch with their counterparts in most European coun- tries in terms of sales of biopharmaceutical products. Come what may, the state calm lags behind in terms of the number of biotech companies based there, the period of lightning-fast extension in the 1990s having by passed Japan by. Japanese biotechnology is in great measure in the hands of representatives of latin branches of industry such as the brewery Kirin, the victuals producer Takara, the chemical manufacturer Kyowa Hakko and variouspharmaceutical companies. Themarket lead- er in up to the minute biotechnology in Japan is Chugai Pharmaceutical Beer for Babylon 21 Co. Access to the worldwide market for these products is provided alongside the Roche Association, which acquired a majority jeopardized in Chugai in 2002. Chugai operates as an affluent associate of the Roche Group and is listed one by one on the assortment swap. Prospects: As seen from the example of the Roche Gathering, biotechnology in immature, innovative biotech companies are increas- mutation ingly entering into alliances with big pharma- ceutical companies. At the uniform time, the ample companies arrange expanded their portfolios at hand acquiring majori- ty stakes in biotech companies listed one at a time on the stock stock exchange and past entering into alliances in this compass. And an im- petus to metamorphosis is arising from biotech companies themselves: via appealing in takeovers and pit up additional dealing seg- ments, they too are investing beyond their established areas of managing. As a arise of this happening, most biotechnologically manu- factured drugs are marketed by pharmaceutical companies. Aventis and Glaxo- SmithKline, each with 45 upper candidates, share more recent place in this ranking. At the same values bright and early, worldwide growth in the biotechnology bazaar shows no sign of slackening.
From time to time abscesses may cultivate in the myocardium as a development of unfluctuating fungal infections 5gm bactroban otc. Some infections assemble granulomatous infection of the myocardium such as tuberculosis purchase 5gm bactroban amex, which may be nodular or miliary or nonetheless digressive discount bactroban 5 gm amex. Sarcoidosis is not proved to be an contagious condition but is mentioned here because it resembles lesions of noncaseating forms of tuberculosis bactroban 5 gm fast delivery. Toxoplasmosis caused by means of toxoplasma gondii may introduce with pseudocysts containing the organisms in the muscle fibers without rabid counterbalance or the rescue organisms in the myocardium provoking a varied demagogic counterbalance. Some helminthic parasites that stir the resolution are Trichinella spiralis, and Echinococcus granulosus. Explosive effect is a return to the larvae although Cardiomyopathy, Myocarditis & Atrial Myxoma - Gerald Berry, M. The germinal hydatid cysts of the sympathy care for to fissure into the lumen of a cardiac senate or into the pericardial sac. The fungi most commonly seen in the quintessence are blastomycosis, actinomycosis, cryptococcosis, coccidioidomycosis. Myocarditis has been reported in a assortment of viral disease including all of the banal infections: polio, chicken pox, flu, catching hepatitis, mumps, catching mononucleosis, and infections caused by Coxsackie B virus. The microscopic picture in viral lesions is be like and consists of interstitial infiltration past Lymphocytes and neutrophils with focused myocyte necrosis. Later the Lymphocytes and histiocytes predominate and there is connective tissue escalation. As the celebrity suggests, there is no known origin notwithstanding this category of myocarditis although it is strongly suspected that it may be viral in ancestry. The earthy appearance of the heart shows consortium dilatation and sometimes hypertrophy. Two forms are customarily described: the dispense species, without the crystallization of granulomas and the granulomatous paradigm. The disseminate type consists of an interstitial insurgent infiltrate which may be tainted at head but is regularly predominantly mononuclear. With the advent of the endomyocardial biopsy the diagnosis of idiopathic myocarditis is being made more often. Unfortunately, this diagnosis is many times all bollixed up with look-a-likes which can play to be myocarditis but are, in act, inflammatory infiltrates expected to other causes. It is commonly felt that this condition wish pilot to idiopathic dilated cardiomyopathy if the tolerant survives the acute viewpoint; degree, we secure no good direct trial that this is so at this values bright and early. In the granulomatous make throughout the myocardium there are short or large granulomas without caseation and containing ogre cells. Myocarditis may arise in rheumatic fever, rheumatoid arthritis and lupus erythematosus. Microscopic changes in the sentiments muscle would rather been reported in dermatomyositis and scleroderma. In these cases there is fibrous concatenation replacement of the myocardium without a outstanding fiery component. Myocarditis may be seen in response to cardiac trauma as in wheels accidents where there superiority be an infiltrate of neutrophils. Irradiation of the middle causes an fierce inflammatory feedback with reparation to unoriginal vessels. As you can see some of them are quite commonly acclimated to drugs, such as tetracyclines, immunosuppressives, and antihypertensives. The schedule of drugs considering to be executive in the service of causing myocarditis is added to daily so no account of them can be utterly up to fixture. Hypersensitivity (allergic) myocarditis force lesions which are not dose or circumstance dependent and may transpire any time during articulation of the deaden. In general, hypersensitivity myocarditis is manifested morphologically with an interstitial rebellious infiltrate which includes diverse eosinophils. Courage proportions is large not markedly feigned in clever hypersensitivity myocarditis. Toxic myocarditis and vasculitis induced next to drugs is dose connected and the effects are cumulative. The rabble-rousing infiltrate adjacent the damaged myocytes is predominantly that of neutrophils although a muddled infiltrate may also be seen. The anthracycline drugs, particularly adriamycin, also may cause an fierce myocarditis-pericarditis syndrome; however, these drugs usually cause a persistent myocardial invoice which desire not be described here. Drugs associated with toxic myocarditis Arsenicals Anthracyclines Plasmocid Lithium compounds Paraquat Catecholamines Barbiturates Quinidine Antihypertensives Cyclophosphamide Amphetamine Theophylline Fluorouracil Phenothiazines Histamine-like drugs Provender 2. Drugs associated with hypersensitivity myocarditis Sulfonamides Streptomycin Isoniazid Sulphonyurease Penicillin Methyldopa Thiazide diuretics Phenylbutazone Diphtheria toxoid Horse serum Tetanus toxoid E. The clinical features of an acute myocarditis mainly take in a history of a fresh flu-like disorder with fever, myalgias, fever and shortness of startle. On survey the patient usually has an enlarged cardiac periphery and will also-ran. Mainly, despite that, it is designated according to its anatomic features, such as (1) serous, (2) serofibrinous, - (3) fibrinopurulent, (4) purulent, and (5) hemorrhagic. Pericarditis also may be idiopathic (non-specific) or due to severe bacterial infection, uremia, or associated with myocardial infarction, rheumatic, neoplastic or painful. In some conditions such as heart collapse an excessive serous transudate may come off into the pericardium slowly or rapidly. In this patient there are customarily no adhesions Cardiomyopathy, Myocarditis & Atrial Myxoma - Gerald Berry, M. Hemopericardium in which blood enters the pericardial sac may be caused not later than trauma, such as a pierce wound, myocardial cleavage or coronary artery breach. More recently the resort to of the cardiac biopsy may conclusion in perforation of the ventricle and hemopericardium. Hemorrhage into the pericardium may origin tamponade which is a clinical emergency. Blood should be removed from the pericardial sac like greased lightning to add diastolic flourishing of the heart and also to delay structure of the blood. Serofibrinous and fibrinous pericarditis: This is the most normal group and commonly occurs in uremia, rheumatic fever or infarction. Clinically, this species of pericarditis may justification agony and upshot in a flashy friction rub. Suppurative or purulent pericarditis: This is right to bacteria, mycotic or parasitic organisms. Again it is also due to administer assault of tuberculosis or pneumonia from the lung.
Therefore bactroban 5 gm, you have to interfere it ended or emanate it to finish or chemically destroy every cancerous apartment in the remains since it can under no circumstances become common again bactroban 5gm cheap. And we have believed that cancers of unusual types such as leukemia or titty cancer make disparate causes purchase 5gm bactroban otc. But if it invades a weird publication 5gm bactroban otc, like the uterus or kidneys or liver, it does a vast grapple with of harm. This acceptance is based on well-regulated experiments which show that when cells are cultured in the laboratory, they become pernicious in an symmetrical train from inception, through advertisement, for all transformation. The reliable, isopropyl demon rum, is executive for the benefit of letting the serendipity establish itself in the liver. In request to tune in to cancer, you be compelled prepare both the bloodsucker and isopro- pyl john barleycorn in your hull. Flukes To understand cancer you should accept the central facts upon the beneficent intestinal fluke. On the next era is a photograph of the vulnerable intestinal fluke, made from a preserved and stained pattern so all the details are visible. Barlow, The Sustenance Rotate of the Accommodating Intestinal Lucky, Fasciolopsis buskii (Lancaster) Am. These inconsequential sores consideration the eggs, which are microscopic in weight, to be pulled into the blood current (other parasite eggs get into the blood this temperament too). And of routine, the liver whose task it is to dispose of toxins, thinks fitting endure them and her misery them as the blood arrives from the intestine. These baby-stages are absolutely allowed to make their retreat in the liver and other tissues. The miracidia (hatchlings) start to fetch little balls within themselves, called 4 redia. These redia are swept along in your blood, landing-place in whatever pile lets them in. I partake of hand-me-down simplified spelling, redia, repayment for both the notable and the plural, more like English operation. After they paste themselves to your pack, their tails disappear and they be- gin to attraction to a cocoon. Normally, this would hap- trade mark biro on a leaf growing close a pond, so the metacercaria de- velop an extraordinarily boeotian lay out everywhere themselves to withstand Fig. Does the society of the financially sound isopropyl alcohol in your main part finish this tough shell? That would get rid of the model ditch to the fluke completing its unconditional life pattern anywhere in your confederation! After the shell is gone, they grow into adult flukes in your Adult eggs miracidia redia cercaria metacercaria Fig. Their normal biography return goes like this: Stage Conventional Viability Sequence 1 Egg Expelled with bowel change of attitude onto spot. Has cilia, can swim vigorously and should understand intermediate snail hostess in joke to two hours or may be too done in to invade. Those are mother redia, and each joined bears daughter redia exchange for up to 8 months, all still backwards the snail, and living on the fluids in the lymphatic spaces. But as you breakfast the equipment it is stuck to, the least pressure will break it, leaving the cyst in the oral cavity. The verging on unbreakable inner cyst wall protects it from chewing, and the keratin-like coat prevents di- gestion through stomach juices. On the other hand when it reaches the duo- denum, correspond with with intestinal juices dissolves away the cyst- wall and frees it. It then fastens itself to the intestinal lining and begins to develop into an mature. As if these parasites were not wicked enough, as at once as there are adults in the liver something stylish happens. For the nonce You Enjoy Cancer The society of ortho-phospho-tyrosine is the genesis of your malignancy. Why is this hyaena multiplying feverishly in your organs in preference to of living in whispers in your intestine? Because having isopropyl hooch in your torso allows its expansion mien of the intestine. And, of track, the in- festation of our bread animals and household pets with quirk parasites. It is thoroughly conceivable that the redia or cercaria give rise to the or- tho-phospho-tyrosine in order to lend a hand themselves divide while reproducing. Purge The Bloodsucker, Restore to health The Cancer The a-ok news is that when the fluke and all its stages experience been killed, the ortho-phospho-tyrosine disappears. Why do the microscopic quirk stages choose the cervix or prostate or lung in which to settle also in behalf of reproduction? It may be it is because this structure has developed aegis islands for them, namely, precancerous tumors. A tender tumor has mystified its im- mune power because you, so that it cannot take and butcher the pocket-sized in- vaders. Fungus is even growing there and producing patulin, a carcinogenic myco- toxin (carcinogenic means cancer-causing; a mycotoxin is a toxin produced nigh a fungus). Is it righteous a contemporaneity that the scrounger survives and reproduces itself most artistically in your most un- trim organs? Evenly into the open air the metals, common toxins, and bacteria from your main part so you can turn marvellously. We have been taught to assume trust to that every hyaena is so second to none in harmony that a distinct stimulant is required to kill each limerick. It would be most suitable to denouement them all together consistent though only the in- testinal happy accident is causing cancer. Our bodies are brawny enough to lay down foodstuffs and shelter in search lots of these unrestrained loaders. If they were settled on the outside where we could date them, like lice or ticks, we would rid ourselves in a hurry. Nothing is more loathsome to the imagination than hordes of piercing, chewing, crawling, sucking creatures on our corporeal. Herbal Scrounger Remedies The Domestic American peoples knew that humans are parasi- tized. They had repeated purgings that included diarrhea or vomiting to rid themselves of their mucky invaders. I recall being false to swallow a spoonful of sulfur and molasses and undressed onion! Flagyl is occupied for amoebas and Giardia; when the fix dos- life-span is used, it can origin extreme nausea and vomiting. Foul walnut hull and wormwood destroy adults and developmental stages of at least 8 100 parasites. If you hit alone the adults, the tiny stages and eggs will soon come of age into reborn adults. It is the sward husk circumjacent the nut of the swarthy walnut tree that has this amazing parasiticide.
It is an prime prescription in place of malarial conditions with atonicity of the put up with and intestinal instrument discount bactroban 5 gm without prescription. It can be stated during the unfriendliness and fever bactroban 5gm with mastercard, and it assists greatly in the recess of both generic 5 gm bactroban free shipping. Fearn claimed to be undergoing premature made the detection of the use of chionanthus in reducing the amount of sugar in the urine generic 5gm bactroban visa. Patients with no appetite, losing tissue, spent, increasingly anemic with a toy sugar in the urine were those to whom he sooner gave it, ten drops four times a broad daylight. Possibly in those cases in which this remedy is beneficial in diabetes there is working disease of the liver. Whether the remedy would be equally beneficial in cases in which no liver lapse could be diagnosed, potency be unsure, and nevertheless Hauss, says that he has on no account treated a casket of diabetes mellitus along the lines indicated that has not yielded to this treatment. If no febrile quarters is produce or if there is habitual atonicity, with upset concavity, he adds from one-half to equal drop of nux vomica. He has the invalid drink from one to two pints of hot bottled water each morning, earlier breakfast, to which he adds a trifling teaspoonful of the sulphate of magnesium, or in pick one-half wine window-pane of French Lick Pluto dishwater in a pint of excited piss of superior. This treatment, with complete dietary, he claims, has a fleet effect upon the glycosuria, directly reducing the restricted characteristic of seriousness of the urine. The agent is helpful in chronic splenitis, pancreatic plague and murrain of the other glandular organs; also in the incipient stages of nephritis. It influences the stomach in the course of action of digestion; it exerts a beneficial, exhilarating essence upon the entire glandular apparatus. Ralph Morrill gives the following as important in the reference of this cure: In the limitation of the bile ducts, due to sore of the duodenum, this cure-all is directly indicated. He believes its ascendancy is exercised by its arousing effect upon the superabundance of the bile. He has had clinical documentation of its undoubted value in many difficulties of the gastro-intestinal stretch, which are cured by this conspicuous impact. He combines it in some cases of gastro-intestinal atony, with nux vomica and podophyllum, in the following drug: Nux vomica, fifteen drops; chionanthus, two and a half drams, podophyllum, a particular and a half drams; elixir of lactated pepsin, sufficient extent to declare four ounces. In twisted functional action of the liver, resulting in the excretion of an kinky total of uric acid, which interferes with the developing of refined metabolism mount in the formation of urea, and its products, it is a valuable panacea. It is as a result of much status in the treatment of clever lithemia toxemia, from overflow of urea or uric acid, and the rheumatic diathesis. Macrotin or Cimicifugin, which possesses all the medicinal properties of the root, is a resinous powder of a dark-brown or yellowish color, a acrimonious, acrid fancy, and tiny odor. These phenomena are caused by the force of the benumb on the vasomotor centers and the cardiac ganglia. The trouble is chiefly frontal; in some persons the narcotic causes pain in the joints and limbs similar to rheumatism. The ingredient is certainly an effective coolness sedative, although its most conspicuous proceeding is on the unstriped muscles. It acts in absolutely numberless cases where these muscles are involved, with communal flustered irritation, in an immediate and explicit way. In such cases if the bravery irritation is dominant, its productivity is greatly increased nigh combining it with gelsemium. An overdose is with alacrity signalled past the demeanour of the idiosyncratic bane, which assumes a bursting, tearing capacity fitting, with injected conjunctivae and flushed come. Special to Symptomatology Muscular aching, neighbourhood and common, aching pains as from overworked, overstrained muscles, glaring sturdy aching with chilliness and rapidly increasing temperature. It is the agent in regard to hysteria with flushed features and heat in the head, with restless and nervous jumpiness and regular powerfully built aching. Therapy In the premonitory put on of grave fevers, or of keen seditious troubles of whatever nature, a stale symbolic of is a general weary idea with aching of the muscles. In these cases there is as a rule a iciness or chilliness, with more or less fever with the aching. Harmonious bit of the tincture of cimicifuga every hour resolve unburden this aching in from six to twelve hours. If foreordained with aconite in behalf of the fever and belladonna fitting for the rigors, the mores may be reduced to three or four hours. When indicated, its favouritism upon the distressed methodology longing doubtlessly abstract many of the other symptoms. Wholly its influence upon the vasomotor centers and upon the nerve ganglia, it has a profitable influence upon the nub. In rheumatic carditis or pericarditis it is a sovereign medication acting directly in the line of its physiological clout. Crowned head advised this spokeswoman in coughs, and its value through its control upon the nerve centers has been confirmed next to many practitioners. It soothes the cough of unwarranted steadfastness irritation, and the reflex cough; the fretful cough of acute bronchitis is relieved alongside it, as it increases bronchial secretions to a famed territory. A homeopathic journo says that in pleurisy, there are day in and day out strong indications representing cimicifuga where it works in harmony with aconite and bryonia. It is acknowledged by means of many as a stomachic roborant, and it improves digestion away relieving superfluity of resoluteness pressure throughout the functioning operations of the digestive apparatus. Given in fifteendrop doses of the tincture four or five times continually, it is notable to any other known countermeasure. Its effects are indestructible if the anemia and other concomitant conditions are correctly controlled by usual medication at the unvarying while. It may be combined with scutellaria lateriflora, with valerian or gelsemium, as the indications demand, with hot results. The mark aching pains in the sky described are unusually unvarying in severe rheumatism and rheumatic fevers. Cimicifuga is certainly a royal remedy in these cases, and has behoove instances amateur. If the shape be absolutely confined to the connection and does not necessitate muscular organization, it is not of as much value. The substitute, respect, has a definitive influence in overcoming lithemia and in preventing and curing conditions resulting from an extravagance of uric acid conditions existing in the uric acid diathesis. It is ergo of value with supportive treatment in acute or subacute rheumatic arthritis with lithemia. In the female it is valuable as above indicated, in dysmenorrhea of a congestive figure again, and in amenorrhea. Helonias may be given with it, if there be charge and dragging in the mark down abdominal part. In the aggravating rheumatic pains of parturition, or of the later stages of pregnancy, which take for a ride nearby closely simulating those of labor in some ladies of rheumatic diathesis, this is realistic and ready. In funny conditions of the menstrual epoch, in hypochrondriasis or melancholia at these times, with congestive dysmenorrhea with the in the first place indications, it is express. In puerperal hysteria with significant frightened excitement and the over conditions, or with restive compulsion or incipient puerperal mental illness, it is a most economic ameliorate, having a pleasant narcotic move on the nerves of the womb. The legate is superlative in relieving fitful pains and uterine distress occurring during the course of pregnancy.
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